Pope Benedict XVI made a call to the heavens today, but this time it was not a prayer.

For the first time in history a pope spoke live to astronauts in orbit.

The Pope spoke to the International Space Station crew, who were joined by the STS-134 Endeavour crew in a video call. He made the special call from The Vatican Library in Rome.

The Endeavour crew is there in the next-to-the-last Shuttle mission ever to deliver the powerful AMS detector to the station.

The Pope and the astronauts talked about the remarkable vantage point over Earth that the space station offers, as well as the environment, science, global cooperation and other topics.

Here's a link to more information in a Fox News story.